Clinical Efficacy of Cefixime for the Treatment of Early Syphilis.

Authors :: Stafylis C
Keith K
Mehta S
Tellalian D
Burian P
Millner C
Klausner JD
Source :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Sep 07; Vol. 73 (5), pp. 907-910.
Publication Year :: 2021
Abstract: Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%-100%; 13/15). Clinical Trials Registration. NCT03752112.<br /> (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)

Subjects :: Anti-Bacterial Agents therapeutic use
Cefixime therapeutic use
Humans
Pilot Projects
Syphilis Serodiagnosis
Treatment Outcome
Treponema pallidum
Syphilis drug therapy

Language :: English
ISSN :: 1537-6591
Volume :: 73
Issue :: 5
Database :: MEDLINE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :: Academic Journal
Accession number :: 33640982
Full Text :: https://doi.org/10.1093/cid/ciab187