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Changes in DNA-binding activity of transcription factors in the kidney of mice exposed to cadmium.
- Source :
-
The Journal of toxicological sciences [J Toxicol Sci] 2021; Vol. 46 (3), pp. 125-129. - Publication Year :
- 2021
-
Abstract
- Cadmium (Cd) is a toxic heavy metal, long-term exposure to which causes renal damage associated with disruption in gene expression. Transcription factors whose activities were altered in the kidneys of mice exposed to Cd for 3 months were assessed using protein/DNA-binding assays. Female C57BL/6J mice were exposed to 300 ppm Cd in the diet for 3 months. Nuclear extracts of kidney were used for protein/DNA-binding assays. The concentration of Cd was approximately 100 ppm in mouse kidney, a level that did not induce renal toxicity. Among the 345 transcription factors evaluated, five transcription factors showed over a two-fold increase in their activities and 14 transcription factors showed a half-fold change in their activities after Cd exposure. These findings may provide new information about the causative transcription factors associated with Cd renal toxicity.
Details
- Language :
- English
- ISSN :
- 1880-3989
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of toxicological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33642518
- Full Text :
- https://doi.org/10.2131/jts.46.125