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Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions.
- Source :
-
Scientific reports [Sci Rep] 2021 Mar 03; Vol. 11 (1), pp. 5083. Date of Electronic Publication: 2021 Mar 03. - Publication Year :
- 2021
-
Abstract
- Obesity, a growing health concern, is associated with an increased risk of morbidity and mortality. Chronic low-grade inflammation is implicated in obesity-driven metabolic complications. Peripheral focused ultrasound stimulation (pFUS) is an emerging non-invasive technology that modulates inflammation. Here, we reasoned that focused ultrasound stimulation of the liver may alleviate obesity-related inflammation and other comorbidities. After 8 weeks on a high-fat high-carbohydrate "Western" diet, C57BL/6J mice were subjected to either sham stimulation or focused ultrasound stimulation at the porta hepatis. Daily liver-focused ultrasound stimulation for 8 weeks significantly decreased body weight, circulating lipids and mitigated dysregulation of adipokines. In addition, liver-focused ultrasound stimulation significantly reduced hepatic cytokine levels and leukocyte infiltration. Our findings demonstrate the efficacy of hepatic focused ultrasound for alleviating obesity and obesity-associated complications in mice. These findings suggest a previously unrecognized potential of hepatic focused ultrasound as a possible novel noninvasive approach in the context of obesity.
- Subjects :
- Adipokines blood
Adipose Tissue metabolism
Adipose Tissue radiation effects
Adiposity radiation effects
Animals
Cytokines blood
Diet, High-Fat adverse effects
Diet, Western adverse effects
Inflammation metabolism
Inflammation therapy
Liver metabolism
Male
Mice
Mice, Inbred C57BL
Obesity etiology
Signal Transduction radiation effects
Weight Gain radiation effects
Lipid Metabolism radiation effects
Liver radiation effects
Obesity blood
Obesity therapy
Ultrasonic Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33658532
- Full Text :
- https://doi.org/10.1038/s41598-021-84330-6