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B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies.
- Source :
-
Cell host & microbe [Cell Host Microbe] 2021 Apr 14; Vol. 29 (4), pp. 564-578.e9. Date of Electronic Publication: 2021 Mar 03. - Publication Year :
- 2021
-
Abstract
- Determining which immunological mechanisms contribute to the development of broad neutralizing antibodies (bNAbs) during HIV-1 infection is a major goal to inform vaccine design. Using samples from a longitudinal HIV-1 acute infection cohort, we found key B cell determinants within the first 14-43 days of viremia that predict the development of bNAbs years later. Individuals who develop neutralization breadth had significantly higher B cell engagement with the autologous founder HIV envelope (Env) within 1 month of initial viremia. A higher frequency of founder-Env-specific naive B cells was associated with increased B cell activation and differentiation and predictive of bNAb development. These data demonstrate that the initial B cell interaction with the founder HIV Env is important for the development of broadly neutralizing antibodies and provide evidence that events within HIV acute infection lead to downstream functional outcomes.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1934-6069
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cell host & microbe
- Publication Type :
- Academic Journal
- Accession number :
- 33662277
- Full Text :
- https://doi.org/10.1016/j.chom.2021.01.016