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The value of melanoma inhibitory activity and LDH with melanoma patients in a Chinese population.
- Source :
-
Medicine [Medicine (Baltimore)] 2021 Feb 26; Vol. 100 (8), pp. e24840. - Publication Year :
- 2021
-
Abstract
- Abstract: Malignant melanoma is a highly malignant tumor originating from the melanocytes of the neural crest, which is prone to metastasis and has a poor prognosis. Previous research demonstrated that melanoma inhibitory activity (MIA) and lactate dehydrogenase (LDH) could serve as serum markers in malignant melanoma and indicate prognosis in the Caucasian race. Researchers suspected that both MIA and LDH could prompt the prognosis of malignant melanoma in the Chinese population. This study aimed to investigate the value of MIA and LDH in the prognosis of acral malignant melanoma.From January 1, 2014, to December 31, 2017, in Jiangsu Province, 44 acral malignant melanoma patients with complete data were chosen from the clinic. The LDH levels were extracted from their clinical data, and MIA levels were measured by enzyme-linked immunosorbent assay method. 8 paired advancing samples before and after metastasis were examined. 22 health donors were matched to the patient group. Receiver operating characteristic (ROC) curves of MIA and LDH were drawn to determine acral malignant melanoma tumorigenesis and metastasis and finally got the cut-off value. Cumulative survival was illustrated with the Kaplan-Meier plot, and factors were compared using the Log-rank test.Compared with age-matched healthy donors, MIA was significantly high in patients (Pā<ā.001). Moreover, serum MIA was significantly higher in III-IV stage patients than I-II stage patients (Pā<ā.001). However, there was no such association between LDH and melanoma stage and risk. Further study indicated that the MIA cut-off > 914.7pg/mL predicted disease progression with 86.4% specificity and 95.5% sensitivity. In the Kaplan-Meier analysis, MIA levels were independent risk factors for long-term mortality of acral malignant melanoma patients.It concluded that the quantification of MIA in the serum should be performed as a general standard of care in patients at risk of developing metastatic melanoma.<br />Competing Interests: The authors have no conflicts of interest to disclose.<br /> (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Subjects :
- Aged
Asian People
Biomarkers blood
Case-Control Studies
China
Enzyme-Linked Immunosorbent Assay
Female
Humans
Kaplan-Meier Estimate
L-Lactate Dehydrogenase blood
Male
Melanoma mortality
Middle Aged
Neoplasm Staging
Retrospective Studies
Skin Neoplasms mortality
Melanoma, Cutaneous Malignant
Extracellular Matrix Proteins blood
Melanoma blood
Melanoma genetics
Neoplasm Proteins blood
Skin Neoplasms blood
Skin Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 100
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33663104
- Full Text :
- https://doi.org/10.1097/MD.0000000000024840