Salchaetoglobosins A and B: Cytochalasan alkaloids from Chaetomium globosum D38, a fungus derived from Salvia miltiorrhiza.

Authors :: Ji J
Liu C
He X
Chen G
Qin L
Zheng C
Source :: Fitoterapia [Fitoterapia] 2021 Jun; Vol. 151, pp. 104874. Date of Electronic Publication: 2021 Mar 03.
Publication Year :: 2021
Abstract: Chemical investigation on the solid rice culture of Chaetomium globosum D38, an endophytic fungus derived from Salvia miltiorrhiza, has afforded two new 19,20-seco-chaetoglobosins, salchaetoglobosins A (1) and B (2), along with three known analogues, chaetoglobosins E (3), Fex (4), and V <subscript>b</subscript> (5). Their structures and absolute configurations were elucidated by a set of spectroscopy and single-crystal X-ray crystallography. Compounds 1-5 were evaluated for their cytotoxic activities against HCT-116 (colorectal carcinoma) and PC3 (prostate cancer) cells, as well as the NO production inhibitory effects in LPS-stimulated RAW264.7 cells.<br /> (Copyright © 2021. Published by Elsevier B.V.)

Subjects :: Animals
Anti-Inflammatory Agents isolation & purification
Antineoplastic Agents isolation & purification
China
Drug Screening Assays, Antitumor
HCT116 Cells
Humans
Indole Alkaloids isolation & purification
Mice
Molecular Structure
Nitric Oxide metabolism
PC-3 Cells
RAW 264.7 Cells
Anti-Inflammatory Agents pharmacology
Antineoplastic Agents pharmacology
Chaetomium chemistry
Indole Alkaloids pharmacology
Salvia miltiorrhiza microbiology

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