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Recent Advances in Biomarkers and Regenerative Medicine for Diabetic Neuropathy.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 25; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 25. - Publication Year :
- 2021
-
Abstract
- Diabetic neuropathy is one of the most common complications of diabetes. This complication is peripheral neuropathy with predominant sensory impairment, and its symptoms begin with hyperesthesia and pain and gradually become hypoesthesia with the loss of nerve fibers. In some cases, lower limb amputation occurs when hypoalgesia makes it impossible to be aware of trauma or mechanical stimuli. On the other hand, up to 50% of these complications are asymptomatic and tend to delay early detection. Therefore, sensitive and reliable biomarkers for diabetic neuropathy are needed for an early diagnosis of this condition. This review focuses on systemic biomarkers that may be useful at this time. It also describes research on the relationship between target gene polymorphisms and pathological conditions. Finally, we also introduce current information on regenerative therapy, which is expected to be a therapeutic approach when the pathological condition has progressed and nerve degeneration has been completed.
- Subjects :
- Animals
Biomarkers blood
Cytokines pharmacology
Diabetic Neuropathies drug therapy
Diabetic Neuropathies genetics
Diabetic Neuropathies physiopathology
Exosomes metabolism
Glyoxal blood
Humans
Inflammation immunology
Inflammation metabolism
Lactoylglutathione Lyase blood
MicroRNAs genetics
MicroRNAs metabolism
Nerve Fibers drug effects
Nerve Fibers pathology
Neurons metabolism
Polymorphism, Genetic
Pyruvaldehyde blood
Toll-Like Receptors blood
Toll-Like Receptors genetics
Toll-Like Receptors metabolism
Cytokines therapeutic use
Diabetic Neuropathies therapy
Neurons drug effects
Regenerative Medicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33669048
- Full Text :
- https://doi.org/10.3390/ijms22052301