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Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition.
- Source :
-
Scientific reports [Sci Rep] 2021 Mar 08; Vol. 11 (1), pp. 5426. Date of Electronic Publication: 2021 Mar 08. - Publication Year :
- 2021
-
Abstract
- Gut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition (SAM) and particularly, the absence of Methanobrevibacter smithii, a key player in energy harvest. Nevertheless, it remains unknown whether this absence reflects an immaturity or a loss of the microbiota. In order to assess that, we performed a case-control study in Mali using a propensity score weighting approach. The presence of M. smithii was tested using quantitative PCR on faeces collected from SAM children at inclusion and at discharge when possible or at day 15 for controls. M. smithii was highly significantly associated with the absence of SAM, detected in 40.9% controls but only in 4.2% cases (pā<ā0.0001). The predictive positive value for detection of M. smithii gradually increased with age in controls while decreasing in cases. Among children providing two samples with a negative first sample, no SAM children became positive, while this proportion was 2/4 in controls (pā=ā0.0015). This data suggests that gut dysbiosis in SAM is not an immaturity but rather features a loss of M. smithii. The addition of M. smithii as a probiotic may thus represent an important addition to therapeutic approaches to restore gut symbiosis.
- Subjects :
- Case-Control Studies
Child
Child, Preschool
Dysbiosis genetics
Dysbiosis microbiology
Female
Humans
Infant
Infant, Newborn
Male
Mali
Severe Acute Malnutrition genetics
Feces microbiology
Gastrointestinal Microbiome
Methanobrevibacter genetics
Methanobrevibacter growth & development
Severe Acute Malnutrition microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33686095
- Full Text :
- https://doi.org/10.1038/s41598-021-84641-8