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Early-onset of type 2 diabetes mellitus is a risk factor for diabetic nephropathy progression: a biopsy-based study.

Authors :
Wu Y
Wang Y
Zhang J
Zhang R
Zhao L
Ren H
Zou Y
Wang T
Wang J
Zhao Y
Qin C
Xu H
Li L
Chai Z
Cooper ME
Tong N
Liu F
Source :
Aging [Aging (Albany NY)] 2021 Mar 03; Vol. 13 (6), pp. 8146-8154. Date of Electronic Publication: 2021 Mar 03.
Publication Year :
2021

Abstract

Several studies show that patients with early-onset diabetes have higher risk of diabetic complications than those diagnosed in middle age. However, whether early-onset of type 2 diabetes mellitus (T2DM) is a risk factor for diabetic nephropathy (DN) progression remains unclear, especially a lack of data in biopsy-confirmed cohort. In This study, we enrolled 257 patients with T2DM and biopsy-confirmed DN to investigate the role of early-onset T2DM in DN progression. Participants were divided into two groups according to the age of T2DM diagnosis: early-onset group (less than 40 years) and later-onset group (40 years or older). We found that patients with early-onset T2DM had higher glomerular grades and arteriolar hyalinosis scores than those in later-onset group. After adjusted for confounding factors, early-onset of T2DM remained an independent predictor of end-stage renal disease (ESRD) for patients with DN. In conclusion, although with the comparable renal function and proteinuria, patients with early-onset T2DM and DN had worse renal pathological changes than those with later-onset. Early-onset of T2DM might be an important predictor of ESRD for patients with DN, which called more attention to early supervision and prevention for patients with early-onset T2DM and DN.

Details

Language :
English
ISSN :
1945-4589
Volume :
13
Issue :
6
Database :
MEDLINE
Journal :
Aging
Publication Type :
Academic Journal
Accession number :
33686955
Full Text :
https://doi.org/10.18632/aging.202624