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A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury.
- Source :
-
Scientific reports [Sci Rep] 2021 Mar 11; Vol. 11 (1), pp. 5653. Date of Electronic Publication: 2021 Mar 11. - Publication Year :
- 2021
-
Abstract
- Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery.
- Subjects :
- Animals
Bone Marrow Cells radiation effects
Bone Marrow Transplantation
Cell Movement radiation effects
Cell Proliferation radiation effects
Chemokine CCL17 metabolism
Dermis pathology
Dermis radiation effects
Epidermis pathology
Epidermis radiation effects
Gene Deletion
HaCaT Cells
Humans
Keratinocytes radiation effects
Macrophages radiation effects
Mice, Inbred C57BL
Mice, Transgenic
Radiation, Ionizing
Receptors, CCR4 deficiency
Receptors, CCR4 metabolism
Signal Transduction radiation effects
Skin pathology
Skin radiation effects
Mice
Bone Marrow Cells pathology
Keratinocytes pathology
Radiation Injuries pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33707490
- Full Text :
- https://doi.org/10.1038/s41598-021-84818-1