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Giant cell arteritis with ocular involvement successfully treated with tocilizumab and very short-course glucocorticoids: A case report.

Authors :
Khanna RK
Hage R
Lecler A
Sene T
Vignal-Clermont C
Clavel-Refregiers G
Source :
Journal francais d'ophtalmologie [J Fr Ophtalmol] 2021 Apr; Vol. 44 (4), pp. 481-484. Date of Electronic Publication: 2021 Mar 10.
Publication Year :
2021

Abstract

Purpose: To report the case of a patient with arteritic anterior ischemic optic neuropathy (AAION) with a history of glucocorticoids (GC) hypersensitivity treated with monthly intravenous tocilizumab (IV TCZ) and short course of GC.<br />Case Report: A 71-year-old Caucasian patient presented with AAION related to giant cell arteritis (GCA) confirmed by temporal artery biopsy. Past medical history was significant for GC hypersensitivity proven by allergy evaluation and the patient was managed with IV TCZ and very short-course GC.<br />Conclusion: TCZ therapy with very short-course GC could be effective in GCA with ophthalmic involvement as a first-line strategy. Clinical trials are needed for thorough evaluation of the efficiency of TCZ as a first-line treatment to induce and maintain remission in patients with GCA and ocular involvement.<br /> (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)

Details

Language :
English
ISSN :
1773-0597
Volume :
44
Issue :
4
Database :
MEDLINE
Journal :
Journal francais d'ophtalmologie
Publication Type :
Academic Journal
Accession number :
33712335
Full Text :
https://doi.org/10.1016/j.jfo.2020.08.028