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n -Propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside is a good inhibitor for the β-galactosidase from E. coli .
- Source :
-
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2021; Vol. 30 (5), pp. 1099-1107. Date of Electronic Publication: 2021 Mar 05. - Publication Year :
- 2021
-
Abstract
- A convenient route has been developed for the synthesis of novel 6-amino-2,2-(or 3,3-difluoro)-2-(or 3),6-dideoxy-hexopyranoses. Biological screening showed these compounds as good inhibitors for several glycosidases. Especially n -propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside ( 8 ) was an excellent competitive inhibitor for the β-galactosidase from E. coli holding a K <subscript> i </subscript> of 0.50 μM.<br />Competing Interests: Conflict of interestThe authors declare no competing interests.<br /> (© The Author(s) 2021.)
Details
- Language :
- English
- ISSN :
- 1054-2523
- Volume :
- 30
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents
- Publication Type :
- Academic Journal
- Accession number :
- 33716475
- Full Text :
- https://doi.org/10.1007/s00044-021-02715-8