Claudin-4 Immunoexpression in Urothelial Carcinomas.

Authors :: SĂndulescu AŞ
Stepan AE
MĂrgĂritescu C
Badiu AM
Matei M
Simionescu CE
Source :: Current health sciences journal [Curr Health Sci J] 2020 Oct-Dec; Vol. 46 (4), pp. 379-382. Date of Electronic Publication: 2020 Dec 31.
Publication Year :: 2020
Abstract: The involvement of claudins in urothelial carcinogenesis is controversial. In this study, we analyzed Claudin-4 immunoexpression in 50 cases of bladder urothelial carcinomas depending on the main prognostic parameters of the lesions represented by the tumor grade and tumor extension. Claudin-4 immunoexpression scores were significantly higher in high-grade urothelial carcinomas and in tumors with invasion in muscularis propria. The results obtained indicate the involvement of Claudin-4 in the progression of urothelial bladder carcinomas.<br />Competing Interests: None to declare.<br /> (Copyright © 2014, Medical University Publishing House Craiova.)