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Alpha-mangostin improves endothelial dysfunction in db/db mice through inhibition of aSMase/ceramide pathway.

Authors :
Jiang M
Huang S
Duan W
Liu Q
Lei M
Source :
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Apr; Vol. 25 (7), pp. 3601-3609. Date of Electronic Publication: 2021 Mar 14.
Publication Year :
2021

Abstract

Diabetic vascular complications are the leading causes of death and disability in patients with diabetes. Alpha-mangostin has been reported to have anti-diabetic capacity in recent years. Here, we investigated the protective function of alpha-mangostin on endothelium in vitro and in vivo experiments. We also observed that alpha-mangostin improved impaired endothelium-dependent vasodilation (EDV) of diabetic animals while it limited the aSMase/ceramide pathway and up-regulated eNOS/NO pathway in aortas from diabetic mice. Meanwhile, alpha-mangostin inhibited elevated aSMase/ceramide pathway and reversed impaired EDV induced by high glucose in isolated mouse aortas. In addition, alpha-mangostin increased phosphorylation of eNOS and NO production in high glucose-treated aortas. Alpha-mangostin normalized high glucose-induced activation of aSMase/ceramide pathway and improved eNOS/NO pathway in endothelial cells with high glucose. In conclusion, alpha-mangostin regulates eNOS/NO pathway and improves EDV in aortas of diabetic mice through inhibiting aSMase activity and endogenous ceramide accumulation.<br /> (© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1582-4934
Volume :
25
Issue :
7
Database :
MEDLINE
Journal :
Journal of cellular and molecular medicine
Publication Type :
Academic Journal
Accession number :
33719188
Full Text :
https://doi.org/10.1111/jcmm.16456