Measurement of intraorgan fat and hepatic output of triglycerides in human type 2 diabetes by magnetic resonance and intralipid infusion techniques.

Liver fat content and the linked rate of export of triglyceride are central to the etiology of type 2 diabetes, as well as to the cardiovascular effects of fatty liver disease. Measurement in humans of intrahepatic and intrapancreatic fat content is described using magnetic resonance techniques and quantification of the rate of hepatic secretion of very low density lipoprotein using a non-isotopic competitive blocking of tissue uptake. This protocol is non-invasive, can be repeated sequentially, and does not involve ionizing radiation. For complete details on the use and execution of this protocol, please refer to (Taylor et al., 2018) and (Al-Mrabeh et al., 2020b).
Competing Interests: R.T. reports lecture fees from Lilly and Novartis, consultancy fees from Wilmington Healthcare, and is author of the book Life Without Diabetes. A.A.-M. report a grant from Diabetes UK to carry out the Re-TUNE study. All other authors report no competing interests.
(© 2021 The Author(s).)