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Covid-19 and gender: lower rate but same mortality of severe disease in women-an observational study.
- Source :
-
BMC pulmonary medicine [BMC Pulm Med] 2021 Mar 20; Vol. 21 (1), pp. 96. Date of Electronic Publication: 2021 Mar 20. - Publication Year :
- 2021
-
Abstract
- Background: Gender-related factors might affect vulnerability to Covid-19. The aim of this study was to describe the role of gender on clinical features and 28-day mortality in Covid-19 patients.<br />Methods: Observational study of Covid-19 patients hospitalized in Bergamo, Italy, during the first three weeks of the outbreak. Medical records, clinical, radiological and laboratory findings upon admission and treatment have been collected. Primary outcome was 28-day mortality since hospitalization.<br />Results: 431 consecutive adult patients were admitted. Female patients were 119 (27.6%) with a mean age of 67.0 ± 14.5 years (vs 67.8 ± 12.5 for males, p = 0.54). Previous history of myocardial infarction, vasculopathy and former smoking habits were more common for males. At the time of admission PaO <subscript>2</subscript> /FiO <subscript>2</subscript> was similar between men and women (228 [IQR, 134-273] vs 238 mmHg [150-281], p = 0.28). Continuous Positive Airway Pressure (CPAP) assistance was needed in the first 24 h more frequently in male patients (25.7% vs 13.0%; p = 0.006). Overall 28-day mortality was 26.1% in women and 38.1% in men (p = 0.018). Gender did not result an independent predictor of death once the parameters related to disease severity at presentation were included in the multivariable analysis (p = 0.898). Accordingly, the Kaplan-Meier survival analysis in female and male patients requiring CPAP or non-invasive ventilation in the first 24 h did not find a significant difference (p = 0.687).<br />Conclusion: Hospitalized women are less likely to die from Covid-19; however, once severe disease occurs, the risk of dying is similar to men. Further studies are needed to better investigate the role of gender in clinical course and outcome of Covid-19.
- Subjects :
- Aged
Aged, 80 and over
COVID-19 mortality
COVID-19 physiopathology
COVID-19 therapy
Comorbidity
Continuous Positive Airway Pressure statistics & numerical data
Diabetes Mellitus epidemiology
Female
Humans
Hypertension epidemiology
Hypoxia epidemiology
Hypoxia physiopathology
Hypoxia therapy
Italy epidemiology
Kaplan-Meier Estimate
Male
Middle Aged
Myocardial Infarction epidemiology
Noninvasive Ventilation statistics & numerical data
SARS-CoV-2
Severity of Illness Index
Sex Factors
Smoking epidemiology
COVID-19 epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2466
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC pulmonary medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33743654
- Full Text :
- https://doi.org/10.1186/s12890-021-01455-0