Therapeutic Escape in Gαq-mutant Uveal Melanoma: It's a FAK.

Authors :: Harbour JW
Source :: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Jun 01; Vol. 27 (11), pp. 2967-2969. Date of Electronic Publication: 2021 Mar 25.
Publication Year :: 2021
Abstract: Through a synthetic lethal screen, ERK activation was found to mediate resistance to FAK inhibition in GNAQ-mutant uveal melanoma. With PLCB-PKC-ERK and Trio-FAK-Yap representing compensatory effectors of mutant Gαq signaling, combined inhibition of both pathways may be a promising therapeutic strategy in metastatic uveal melanoma. See related article by Paradis et al., p. 3190 .<br /> (©2021 American Association for Cancer Research.)

Subjects :: Cell Line, Tumor
GTP-Binding Protein alpha Subunits, Gq-G11 genetics
Humans
Melanoma
Uveal Melanoma
GTP-Binding Protein alpha Subunits genetics
GTP-Binding Protein alpha Subunits metabolism
Uveal Neoplasms genetics

Language :: English
ISSN :: 1557-3265
Volume :: 27
Issue :: 11
Database :: MEDLINE
Journal :: Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Type :: Academic Journal
Accession number :: 33766812
Full Text :: https://doi.org/10.1158/1078-0432.CCR-21-0567