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A Genetic Model Reveals Biological Features of Neonatal CD4 Helper Cells Undergone Homeostasis in Mice.
- Source :
-
Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Mar 11; Vol. 9, pp. 659744. Date of Electronic Publication: 2021 Mar 11 (Print Publication: 2021). - Publication Year :
- 2021
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Abstract
- CD4 <superscript>+</superscript> T cells are essential for regulating effective immune response to pathogens and immune balance. Recent studies have demonstrated the unique features of T cells in neonate mice, such as more sensitive to antigen response and preference toward T helper 2 (Th2) response and regulatory T cells (Tregs) differentiation. However, the biological characteristics of neonatal age-derived CD4 <superscript>+</superscript> T cells following homeostasis remain unclear. Here we utilized a lineage tracing model of TCR δ <superscript> CreER </superscript> R26 <superscript> ZsGreen </superscript> to mark neonatal- and adult-derived CD4 <superscript>+</superscript> T cells followed by a combination analysis of activation, proliferation, survival, and differentiation. Our results showed that neonatal CD4 <superscript>+</superscript> T cells had higher capacity of activation, proliferation, apoptosis, and differentiation toward Th2 and T helper 17 (Th17) lineages, accompanied by a reduced potential for T helper 1 (Th1), T helper 9 (Th9), and Treg lineages. In contrast, tracked neonatal CD4 <superscript>+</superscript> T cells exhibited similar characters of above-mentioned of tracked adult cells in adult mice. Therefore, our data support a natural requirement for CD4 <superscript>+</superscript> T cells to acquire fully-equipped functional potentials of adult cells.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Lei, Zhang, Yang, Su, Liu, Yang, Wang, Zou, Wang, Jiao, Zhang, Zheng, Zhang, Zhang, Shi, Zhou, Sun and Zhang.)
Details
- Language :
- English
- ISSN :
- 2296-634X
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in cell and developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 33777965
- Full Text :
- https://doi.org/10.3389/fcell.2021.659744