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Recent Advances in the Chemistry and Pharmacology of Cryptolepine.
- Source :
-
Progress in the chemistry of organic natural products [Prog Chem Org Nat Prod] 2021; Vol. 115, pp. 177-203. - Publication Year :
- 2021
-
Abstract
- Cryptolepine, the principal constituent of the West African climbing shrub Cryptolepis sanguinolenta, continues to be of interest as a lead to new therapeutic agents, especially for the treatment of protozoal infections and cancer. This contribution reviews the research published in the last decade, highlighting new synthesis routes to cryptolepine and to analogs of this alkaloid, as well as their pharmacology. Studies relating to the use of C. sanguinolenta as an herbal medicine for the treatment of malaria are discussed, as well as the development of analogs of cryptolepine as leads to new agents for the treatment of malaria, trypanosomiasis, and cancer with an emphasis on the pharmacological mechanisms involved. Other potential therapeutic applications include antimicrobial, antidiabetic, and anti-inflammatory activities; the pharmacokinetics and toxicity of cryptolepine are also reviewed.
- Subjects :
- Cryptolepis
Indole Alkaloids pharmacology
Alkaloids pharmacology
Quinolines
Subjects
Details
- Language :
- English
- ISSN :
- 2191-7043
- Volume :
- 115
- Database :
- MEDLINE
- Journal :
- Progress in the chemistry of organic natural products
- Publication Type :
- Academic Journal
- Accession number :
- 33797643
- Full Text :
- https://doi.org/10.1007/978-3-030-64853-4_4