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The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation.
- Source :
-
Cells [Cells] 2021 Mar 07; Vol. 10 (3). Date of Electronic Publication: 2021 Mar 07. - Publication Year :
- 2021
-
Abstract
- Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the expression of a plethora of target genes involved in metabolism, immune reaction, cell differentiation, and a variety of other cellular changes and adaptive responses. PPARs are activated by a large number of both endogenous and exogenous lipid molecules, including phyto- and endo-cannabinoids, as well as endocannabinoid-like compounds. In this view, they can be considered an extension of the endocannabinoid system. Besides being directly activated by cannabinoids, PPARs are also indirectly modulated by receptors and enzymes regulating the activity and metabolism of endocannabinoids, and, vice versa, the expression of these receptors and enzymes may be regulated by PPARs. In this review, we provide an overview of the crosstalk between cannabinoids and PPARs, and the importance of their reciprocal regulation and modulation by common ligands, including those belonging to the extended endocannabinoid system (or "endocannabinoidome") in the control of major physiological and pathophysiological functions.
- Subjects :
- Animals
Gene Expression Regulation
Humans
Ligands
Lipid Metabolism genetics
Mice
Mice, Knockout
Models, Molecular
PPAR alpha chemistry
PPAR alpha metabolism
PPAR delta chemistry
PPAR delta metabolism
PPAR gamma chemistry
PPAR gamma metabolism
PPAR-beta chemistry
PPAR-beta metabolism
Receptors, Cannabinoid chemistry
Receptors, Cannabinoid metabolism
Signal Transduction
Transcription, Genetic
Endocannabinoids metabolism
PPAR alpha genetics
PPAR delta genetics
PPAR gamma genetics
PPAR-beta genetics
Receptors, Cannabinoid genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4409
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- 33799988
- Full Text :
- https://doi.org/10.3390/cells10030586