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α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo.
- Source :
-
Toxins [Toxins (Basel)] 2021 Mar 13; Vol. 13 (3). Date of Electronic Publication: 2021 Mar 13. - Publication Year :
- 2021
-
Abstract
- α-Solanine, a bioactive compound mainly found in potato, exhibits anti-cancer activity towards multiple cancer cells. However, its effects on human choriocarcinoma have not been evaluated. In the present study, we investigated the effect of α-solanine on cell proliferation and apoptosis in human choriocarcinoma in vitro and in vivo. The results showed that α-solanine, at concentrations of 30 μM or below, did not affect the cell viability of the choriocarcinoma cell line JEG-3. However, colony formation was significantly decreased and cell apoptosis was increased in response to 30 μM α-solanine. In addition, α-solanine (30 μM) reduced the migration and invasion abilities of JEG-3 cells, which was associated with a downregulation of matrix metalloproteinases (MMP)-2/9. The in vivo findings provided further evidence of the inhibition of α-solanine on choriocarcinoma tumor growth. α-Solanine suppressed the xenograft tumor growth of JEG-3 cells, resulting in smaller tumor volumes and lower tumor weights. Apoptosis was promoted in xenograft tumors of α-solanine-treated mice. Moreover, α-solanine downregulated proliferative cellular nuclear antigen (PCNA) and Bcl-2 levels and promoted the expression of Bax. Collectively, α-solanine inhibits the growth, migration, and invasion of human JEG-3 choriocarcinoma cells, which may be associated with the induction of apoptosis.
- Subjects :
- Animals
Cell Line, Tumor
Choriocarcinoma metabolism
Choriocarcinoma pathology
Female
Humans
Mice, Inbred BALB C
Mice, Nude
Neoplasm Invasiveness
Pregnancy
Signal Transduction
Tumor Burden drug effects
Uterine Neoplasms metabolism
Uterine Neoplasms pathology
Xenograft Model Antitumor Assays
Mice
Antineoplastic Agents, Phytogenic pharmacology
Apoptosis drug effects
Cell Movement drug effects
Cell Proliferation drug effects
Choriocarcinoma drug therapy
Solanine pharmacology
Uterine Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6651
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- 33805658
- Full Text :
- https://doi.org/10.3390/toxins13030210