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In-Depth Characterization of Stromal Cells within the Tumor Microenvironment Yields Novel Therapeutic Targets.

Authors :
Walter SG
Scheidt S
Nißler R
Gaisendrees C
Zarghooni K
Schildberg FA
Source :
Cancers [Cancers (Basel)] 2021 Mar 23; Vol. 13 (6). Date of Electronic Publication: 2021 Mar 23.
Publication Year :
2021

Abstract

Cells within the tumor stroma are essential for tumor progression. In particular, cancer-associated fibroblasts (CAF) and CAF precursor cells (resident fibroblasts and mesenchymal stromal cells) are responsible for the formation of the extracellular matrix in tumor tissue. Consequently, CAFs directly and indirectly mediate inflammation, metastasis, immunomodulation, angiogenesis, and the development of tumor chemoresistance, which is orchestrated by complex intercellular cytokine-mediated crosstalk. CAFs represent a strategic target in antitumor therapy but their heterogeneity hinders effective treatment regimes. In-depth understanding of CAF subpopulations and knowledge of specific functions in tumor progression will ultimately result in more specific and effective cancer treatments. This review provides a detailed description of CAFs and CAF precursor cells and summarizes possible treatment strategies as well as molecular targets of these cells in antitumor therapies.

Details

Language :
English
ISSN :
2072-6694
Volume :
13
Issue :
6
Database :
MEDLINE
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
33806802
Full Text :
https://doi.org/10.3390/cancers13061466