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Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 22; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 22. - Publication Year :
- 2021
-
Abstract
- The relationship between autoimmunity and changes in intestinal microbiota is not yet fully understood. In this study, the role of intestinal microbiota in the onset and progression of autoimmune lesions in non-obese diabetic (NOD) mice was evaluated by administering antibiotics to alter their intestinal microenvironment. Flow cytometric analysis of spleen cells showed that antibiotic administration did not change the proportion or number of T and B cells in NOD mice, and pathological analysis demonstrated that autoimmune lesions in the salivary glands and in the pancreas were also not affected by antibiotic administration. These results suggest that the onset and progression of autoimmunity may be independent of enteral microbiota changes. Our findings may be useful for determining the appropriate use of antibiotics in patients with autoimmune diseases who are prescribed drugs to maintain systemic immune function.
- Subjects :
- Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents adverse effects
Autoimmune Diseases drug therapy
Cytokines metabolism
Disease Models, Animal
Immune System drug effects
Immune System immunology
Immune System metabolism
Mice
Mice, Inbred NOD
Sialadenitis etiology
Sialadenitis metabolism
Sialadenitis pathology
Anti-Bacterial Agents pharmacology
Autoimmune Diseases etiology
Autoimmunity drug effects
Disease Susceptibility
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33810172
- Full Text :
- https://doi.org/10.3390/ijms22063239