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Combined effects of L-ascorbic acid, citric acid or their sodium salts on tumor induction by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-ethyl-N-(4-hydroxybutyl)nitrosamine in the rat urinary bladder.
- Source :
-
Cancer letters [Cancer Lett] 1988 Jun 30; Vol. 40 (3), pp. 265-73. - Publication Year :
- 1988
-
Abstract
- L-Ascorbic acid, citric acid or their sodium salts (at levels equivalent to 5% sodium L-ascorbate) were fed in the diet simultaneously with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) or N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) (0.025% BBN or 0.021% EHBN) in the drinking water to male F344 rats for 20 weeks to determine whether urinary pH changes affect the carcinogenicity of BBN or EHBN. In the urine, pH was decreased in rats fed the acidic chemicals and increased in rats fed their corresponding sodium salts. Histopathologically, the incidences and numbers of preneoplastic and neoplastic lesions in groups treated with each test chemical were not different from those in control groups except for sodium citrate-treated groups in which induction of carcinomas was higher, resulting from increased intake of either carcinogen and also from increased urinary excretion of main carcinogenic metabolites. These results show that the test chemicals do not affect the carcinogenicity of BBN or EHBN on the rat urinary bladder when simultaneously administered despite significant differences in urinary pH.
- Subjects :
- Animals
Body Weight drug effects
Butylhydroxybutylnitrosamine urine
Citric Acid
Diethylnitrosamine toxicity
Diethylnitrosamine urine
Drug Interactions
Hydrogen-Ion Concentration
Male
Organ Size drug effects
Rats
Rats, Inbred F344
Urinary Bladder Neoplasms pathology
Urinary Bladder Neoplasms urine
Ascorbic Acid pharmacology
Butylhydroxybutylnitrosamine toxicity
Citrates pharmacology
Diethylnitrosamine analogs & derivatives
Nitrosamines toxicity
Urinary Bladder Neoplasms chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3835
- Volume :
- 40
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 3383181
- Full Text :
- https://doi.org/10.1016/0304-3835(88)90085-7