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Human Papillomavirus in Patients With Hypopharyngeal Squamous Cell Carcinoma.
- Source :
-
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2022 Jan; Vol. 166 (1), pp. 109-117. Date of Electronic Publication: 2021 Apr 13. - Publication Year :
- 2022
-
Abstract
- Objective: Assess the testing rates and prognostic significance of human papilloma virus (HPV) status in hypopharynx malignancies.<br />Study Design: Historical cohort study.<br />Setting: National Cancer Database.<br />Methods: Review of the National Cancer Database was conducted between 2010 and 2017 for squamous cell carcinomas (SCCs) of the hypopharynx. We investigated how often the tumors were tested for HPV and whether it was associated with survival outcomes.<br />Results: A total of 13,269 patients with hypopharynx malignancies were identified. Most cases were not tested for HPV status (n = 8702, 65.6%). Of those tested, 872 (19.1%) were positive for HPV and 3695 (80.9%) were negative. The proportion of nonoropharyngeal SCCs tested for HPV increased nearly every year during the study, with roughly one-third of cases (31.9%) being tested in 2017. In the facilities classified as high-testing centers of nonoropharyngeal SCCs of the head and neck, 18.7% of hypopharyngeal tumors were HPV positive. HPV-negative status was associated with worse survival on multivariable analysis. In propensity score-matched analysis controlling for all factors significant in multivariable regression, 2-year survival remained higher in the HPV-positive cohort (77.7% vs 63.1%, P < .001).<br />Conclusions: HPV-positive tumors constitute a sizable minority of hypopharynx tumors and are associated with improved survival. Expansion of HPV testing to hypopharynx malignancies may be warranted.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell diagnosis
Cohort Studies
Databases, Factual
Female
Humans
Hypopharyngeal Neoplasms diagnosis
Male
Middle Aged
Papillomavirus Infections complications
Papillomavirus Infections epidemiology
Prognosis
Survival Rate
United States
Alphapapillomavirus isolation & purification
Carcinoma, Squamous Cell epidemiology
Carcinoma, Squamous Cell virology
Hypopharyngeal Neoplasms epidemiology
Hypopharyngeal Neoplasms virology
Papillomavirus Infections diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6817
- Volume :
- 166
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 33845656
- Full Text :
- https://doi.org/10.1177/01945998211004586