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Clinical outcomes and complications of surgical interventions for multiple myeloma lesions in the extremities and pelvis: A retrospective clinical study.
- Source :
-
Acta orthopaedica et traumatologica turcica [Acta Orthop Traumatol Turc] 2021 Mar; Vol. 55 (2), pp. 159-165. - Publication Year :
- 2021
-
Abstract
- Objective: This study aimed to assess the pain and functional status of patients who underwent various surgical interventions for the stabilization of selected multiple myeloma (MM) lesions in the extremities and pelvis and to investigate the rate of complications requiring reintervention.<br />Methods: Patients with MM who underwent various surgical interventions for the extremity or pelvic lesions were retrospectively reviewed. Change in the pain intensity was assessed using visual analogous scale (VAS) preoperatively, at the time of discharge, and at the final follow-up. Functional status was assessed using the musculoskeletal tumor society (MSTS) scoring system for both upper and lower extremities preoperatively and at the final follow-up. Postoperative complications requiring reintervention, including dislocation, loss of fixation/aseptic loosening of prosthesis, mechanical insufficiency, periprosthetic fracture, infection, or progression of the local disease, were recorded.<br />Results: A total of 49 (20 men and 29 women) previously (23) or newly (26) diagnosed patients with a mean age of 60.8±18.2 years were included in this study. Of these, 6 patients underwent multiple surgeries for different skeletal sites; in total, 57 procedures were performed. The mean follow-up was 47.7±21.63 months. The lesions were localized to the humerus (19), radius (1), pelvis (4), femur (30), and tibia (3). The surgical indications included therapy-refractory pain for 17 patients and pathological fractures due to progression of pre-existing lesions for 12 patients or newly diagnosed lesions with extensive bone destruction at initial presentation for 28 patients. Surgical procedures included prosthetic reconstruction in 32 patients, cement-augmented osteosynthesis in 9, and closed intramedullary nailing in 16. The mean VAS score decreased from 8.75±1.2 preoperatively to 3.21±1.56 at the time of discharge and 1.2±0.42 at the final follow-up. Although a significant decrease was detected between the preoperative and postoperative VAS scores at the time of discharge (p=0.0001), the decrease between the time of discharge and the final follow-up was statistically insignificant (p=0.086). The mean MSTS score significantly improved from 9.1%±6.4% (range: 0%-40%) preoperatively to 76%±14.9% (range: 40%-93.3%) at the final follow-up (p=0.0001). Significantly higher MSTS scores were obtained in the upper extremity than lower extremity/pelvis (p=0.04) and in isolated diaphyseal involvement than metaphyseal or articular involvement (p=0.032). A total of 11 complications requiring reintervention (19.2%) were observed, which included dislocation (3.5%), loss of fixation (5.2%), mechanical insufficiency (3.5%), infection (5.2%), and local tumor progression (1.7%). The rate of complications requiring reintervention was lower but statistically insignificant in the upper extremity (5%; 1/20) than lower extremity/pelvis (27%; 10/37) (p=0.076) and in isolated diaphyseal involvement (6.2%; 1/16) than metaphyseal or articular involvement (24.3%; 10/41) (p=0.079).<br />Conclusion: Although different types of surgeries can achieve pain relief and good function in different anatomical localizations, better functional results with lower complication rates may be obtained following surgical management of MM lesions in the upper extremities and in diaphyseal localizations.<br />Level of Evidence: Level IV, Therapeutic Study.
- Subjects :
- Aged
Female
Fracture Fixation, Intramedullary adverse effects
Fracture Fixation, Intramedullary methods
Fractures, Spontaneous etiology
Fractures, Spontaneous surgery
Functional Status
Humans
Male
Middle Aged
Pain, Postoperative surgery
Retrospective Studies
Bone Neoplasms pathology
Bone Neoplasms surgery
Extremities pathology
Extremities surgery
Multiple Myeloma complications
Multiple Myeloma pathology
Multiple Myeloma surgery
Orthopedic Procedures adverse effects
Orthopedic Procedures methods
Orthopedic Procedures statistics & numerical data
Pelvis pathology
Pelvis surgery
Postoperative Complications classification
Postoperative Complications surgery
Reoperation methods
Reoperation statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 2589-1294
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta orthopaedica et traumatologica turcica
- Publication Type :
- Academic Journal
- Accession number :
- 33847579
- Full Text :
- https://doi.org/10.5152/j.aott.2021.20130