[Bempedoic Acid].

Authors :: Wagner M
Leefmann J
Künzel SR
Schmidt MM
El-Armouche A
Source :: Deutsche medizinische Wochenschrift (1946) [Dtsch Med Wochenschr] 2021 Apr; Vol. 146 (8), pp. 552-558. Date of Electronic Publication: 2021 Apr 14.
Publication Year :: 2021
Abstract: ATP-Citrate-Lyase is a key enzyme of cholesterol biosynthesis. Its liver-specific inhibition by the bempedoic acid opens new possibilities to effectively escalate a cholesterol-lowering therapy while avoiding muscle-related side effects. Herein, we present the properties of this new first-in-class pharmaceutical agent and discuss potential consequences for pharmacotherapy.<br />Competing Interests: A. El-Armouche weist auf Forschungs- und/oder Vortragstätigkeiten hin für Boehringer Ingelheim, Novartis, Bayer, Novo Nordisk, Sanofi Aventis, Daiichi Sankyo und Berlin Chemie. Die anderen Autorinnen/Autoren geben keinen Interessenkonflikt an.<br /> (Thieme. All rights reserved.)