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Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial.

Authors :
Rodríguez-Pardo D
Del Toro MD
Guío-Carrión L
Escudero-Sánchez R
Fernández-Sampedro M
García-Viejo MÁ
Velasco-Arribas M
Soldevila-Boixader L
Femenias M
Iribarren JA
Pulido-Garcia MDC
Navarro MD
Lung M
Corona PS
Almirante B
Pigrau C
Source :
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2021 Nov; Vol. 40 (11), pp. 2411-2419. Date of Electronic Publication: 2021 Apr 16.
Publication Year :
2021

Abstract

Purpose: To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections (early-PJIs) after hip hemiarthroplasty (HHA) for fracture.<br />Methods: Open-label, multicenter RCT comparing fosfomycin-trometamol versus no intervention with a parallel follow-up cohort without ASB.<br />Primary Outcome: early-PJI after HHA.<br />Results: Five hundred ninety-four patients enrolled (mean age 84.3); 152(25%) with ASB (77 treated with fosfomycin-trometamol/75 controls) and 442(75%) without. Despite the study closed without the intended sample size, ASB was not predictive of early-PJI (OR: 1.06 [95%CI: 0.33-3.38]), and its treatment did not modify early-PJI incidence (OR: 1.03 [95%CI: 0.15-7.10]).<br />Conclusions: Neither preoperative ASB nor its treatment appears to be risk factors of early-PJI after HHA. ClinicalTrials.gov Identifier: Eudra CT 2016-001108-47.<br /> (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Details

Language :
English
ISSN :
1435-4373
Volume :
40
Issue :
11
Database :
MEDLINE
Journal :
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Publication Type :
Academic Journal
Accession number :
33864153
Full Text :
https://doi.org/10.1007/s10096-021-04241-2