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Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2021 Nov; Vol. 40 (11), pp. 2411-2419. Date of Electronic Publication: 2021 Apr 16. - Publication Year :
- 2021
-
Abstract
- Purpose: To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections (early-PJIs) after hip hemiarthroplasty (HHA) for fracture.<br />Methods: Open-label, multicenter RCT comparing fosfomycin-trometamol versus no intervention with a parallel follow-up cohort without ASB.<br />Primary Outcome: early-PJI after HHA.<br />Results: Five hundred ninety-four patients enrolled (mean age 84.3); 152(25%) with ASB (77 treated with fosfomycin-trometamol/75 controls) and 442(75%) without. Despite the study closed without the intended sample size, ASB was not predictive of early-PJI (OR: 1.06 [95%CI: 0.33-3.38]), and its treatment did not modify early-PJI incidence (OR: 1.03 [95%CI: 0.15-7.10]).<br />Conclusions: Neither preoperative ASB nor its treatment appears to be risk factors of early-PJI after HHA. ClinicalTrials.gov Identifier: Eudra CT 2016-001108-47.<br /> (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Aged
Aged, 80 and over
Anti-Bacterial Agents therapeutic use
Asymptomatic Infections therapy
Bacteriuria drug therapy
Bacteriuria etiology
Female
Fosfomycin therapeutic use
Humans
Joint Diseases drug therapy
Joint Diseases etiology
Male
Prosthesis-Related Infections drug therapy
Prosthesis-Related Infections etiology
Tromethamine therapeutic use
Arthroplasty, Replacement, Hip adverse effects
Bacteriuria microbiology
Joint Diseases microbiology
Prosthesis-Related Infections microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 40
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 33864153
- Full Text :
- https://doi.org/10.1007/s10096-021-04241-2