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Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals.
- Source :
-
Trends in molecular medicine [Trends Mol Med] 2021 Jul; Vol. 27 (7), pp. 624-626. Date of Electronic Publication: 2021 Apr 14. - Publication Year :
- 2021
-
Abstract
- Host-microbiota interactions are vital for diverse pathophysiological events and may be targeted for innovative therapeutics. Nuclear receptors (NRs) are versatile host sensors of microbial signals that coordinate diverse environmental cues with local and remote adaptions. Harnessing NR-mediated sensory machinery could provide an alternative lynchpin for gut microbiota-oriented drug discovery strategy.<br />Competing Interests: Declaration of Interests The authors declare no conflict of interests.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1471-499X
- Volume :
- 27
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Trends in molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33865719
- Full Text :
- https://doi.org/10.1016/j.molmed.2021.03.007