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Rapid 18 F-labeling via Pd-catalyzed S-arylation in aqueous medium.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Apr 14; Vol. 57 (29), pp. 3547-3550. Date of Electronic Publication: 2021 Mar 19. - Publication Year :
- 2021
-
Abstract
- We report radiolabeling of thiol-containing substrates via Pd-catalyzed S-arylation with 2-[ <superscript>18</superscript> F]fluoro-5-iodopyridine, which is readily accessible using the "minimalist" radiofluorination method. The practicality of the procedure was confirmed by preparation of a novel PSMA-specific PET-tracer as well as labeling of glutathione, Aβ oligomer-binding RD2 peptide, bovine serum albumin and PSMA I&S.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 29
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 33870341
- Full Text :
- https://doi.org/10.1039/d1cc00745a