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Similar therapeutic effects of 125 I seed radiotherapy and γ-ray radiotherapy on lacrimal gland adenoid cystic carcinoma.
- Source :
-
International journal of ophthalmology [Int J Ophthalmol] 2021 Apr 18; Vol. 14 (4), pp. 547-553. Date of Electronic Publication: 2021 Apr 18 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Aim: To evaluate the survival outcomes of patients with lacrimal gland adenoid cystic carcinoma who underwent eye-sparing surgery combined with <superscript>125</superscript> I seed implantation radiotherapy or local external γ-ray radiotherapy.<br />Methods: In this retrospective comparative case series, the clinical records of 27 primary and 8 recurrent patients were reviewed. Univariate and multivariate analyses were used to identify risk factors associated with distant metastasis (DM), and the overall survival (OS) after the initial surgery was analyzed.<br />Results: The median follow-up after radiotherapy was 36mo (range 6-120mo). At the last follow-up after radiotherapy, 26 (74.3%) patients had no evidence of disease, 7 (20%) patients had DM, 2 (5.9%) patients died of DM, and 1 patient with DM was lost to follow-up. Univariate analyses showed that duration of symptoms, bone destruction, T stage classification, and wide excision surgery were risk factors influencing DM ( P <0.05). The 5-year and 10-year OS rates after the initial surgery were 95.8% and 79.9%, respectively. The 5-year DM-free survival and disease-free survival rates after radiotherapy were 66.4% and 52.7%, respectively.<br />Conclusion: <superscript>125</superscript> I seed radiotherapy and local external γ-ray radiotherapy may have similar therapeutic effects in preventing DM. Patients with T1/T2 stage disease have a better prognosis than those with T3/T4 stage disease.<br /> (International Journal of Ophthalmology Press.)
Details
- Language :
- English
- ISSN :
- 2222-3959
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 33875946
- Full Text :
- https://doi.org/10.18240/ijo.2021.04.11