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Prorenin periconceptionally and in pregnancy: Does it have a physiological role?
- Source :
-
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2021 Jun 01; Vol. 529, pp. 111281. Date of Electronic Publication: 2021 Apr 18. - Publication Year :
- 2021
-
Abstract
- Pregnancy demands major cardiovascular, renal and endocrine changes to provide an adequate blood supply for the growing fetus. The renin-angiotensin-aldosterone system plays a key role in this adaptation process. One of its components, prorenin, is released in significant amounts from the ovary and uteroplacental unit. This review describes the sources of prorenin in the periconception period and in pregnancy, including its modulation by in-vitro fertilization protocols, and discusses its potential effects, among others focusing on preeclampsia. It ends with discussing the long-term consequences, even in later life, of inappropriate renin-angiotensin-aldosterone system activity in pregnancy and offers directions for future research. Ultimately, a full understanding of the role of prorenin periconceptionally and during pregnancy will help to develop tools to diagnose and/or prevent reproductive complications.<br /> (Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Angiotensin I genetics
Angiotensin I metabolism
Angiotensinogen genetics
Angiotensinogen metabolism
Female
Fertilization in Vitro
Gene Expression Regulation
Humans
Ovary pathology
Placenta pathology
Pre-Eclampsia metabolism
Pre-Eclampsia pathology
Pregnancy
Renin metabolism
Signal Transduction
Uterus pathology
Ovary metabolism
Placenta metabolism
Pre-Eclampsia genetics
Renin genetics
Renin-Angiotensin System genetics
Uterus metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8057
- Volume :
- 529
- Database :
- MEDLINE
- Journal :
- Molecular and cellular endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 33878417
- Full Text :
- https://doi.org/10.1016/j.mce.2021.111281