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Hsa_circ_0010957 level is increased and sponges microRNA‑125b in CD4 + T cells of patients with systemic lupus erythematosus.
- Source :
-
Molecular medicine reports [Mol Med Rep] 2021 Jun; Vol. 23 (6). Date of Electronic Publication: 2021 Apr 21. - Publication Year :
- 2021
-
Abstract
- Systemic lupus erythematosus (SLE) is a severe autoimmune disorder, the pathogenesis of which remains largely unknown. The present study aimed to investigate the role and mechanism of circular RNAs in the etiopathogenesis of SLE. CD4 <superscript>+</superscript> T cells in patients with SLE expressed higher levels of hsa&#95;circ&#95;0010957 compared with healthy individuals and was a good differentiator of the active from inactive SLE disease. It was also determined that hsa&#95;circ&#95;0010957 mediated microRNA (miR)‑125b/STAT3 signaling and subsequent secretion of inflammatory cytokines interleukin (IL)‑18, IL‑6 and IL‑17, which are important factors in the process of SLE. Hsa&#95;circ&#95;0010957 abrogated the proinflammatory effect of IL‑6 via the blockade of STAT3 signaling. In conclusion, increased hsa&#95;circ&#95;0010957 may be involved in SLE pathogenesis via miR‑125b/STAT3 signaling. Hsa&#95;circ&#95;0010957 promises to be a potential biomarker and therapeutic target for SLE.
Details
- Language :
- English
- ISSN :
- 1791-3004
- Volume :
- 23
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Molecular medicine reports
- Publication Type :
- Academic Journal
- Accession number :
- 33880592
- Full Text :
- https://doi.org/10.3892/mmr.2021.12108