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Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs.
- Source :
-
Biomolecules [Biomolecules] 2021 Apr 25; Vol. 11 (5). Date of Electronic Publication: 2021 Apr 25. - Publication Year :
- 2021
-
Abstract
- A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy.
- Subjects :
- Cellulose analogs & derivatives
Cellulose chemistry
Delayed-Action Preparations pharmacology
Drug Carriers chemistry
Drug Liberation
Ketoprofen chemistry
Ketoprofen pharmacology
Methylene Blue chemistry
Methylene Blue pharmacology
Multifunctional Nanoparticles chemistry
Nanofibers chemistry
Polymers chemistry
X-Ray Diffraction methods
Delayed-Action Preparations chemistry
Drug Delivery Systems instrumentation
Drug Delivery Systems methods
Subjects
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 11
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 33922935
- Full Text :
- https://doi.org/10.3390/biom11050635