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Clinical characterization of benign enterovirus infection in neonates.
- Source :
-
Medicine [Medicine (Baltimore)] 2021 May 07; Vol. 100 (18), pp. e25706. - Publication Year :
- 2021
-
Abstract
- Abstract: Enteroviruses is a group of positive single-stranded RNA viruses ubiquitous in the environment, which is a causative agent of epidemic diseases in children and infants. But data on neonates are still limited. The present study aimed to describe the clinical characteristics of enterovirus infection in neonates and arise the awareness of this disease to general public.Between March 2018 and September 2019, data from all of the neonates diagnosed with enterovirus infection were collected and analyzed from neonatal intensive care unit of Zhangzhou Hospital in Fujian, China.A total of 23 neonates were enrolled. All of them presented with fever (100%), and some with rashes (39.1%). The incidence of aseptic meningitis was high (91.3%), but only a small proportion (28.6%) presented with cerebrospinal fluid (CSF) leukocytosis. The positive value for nucleic acid detection in CSF was significantly higher than throat swab (91.3% vs 43.5%, Pā=ā.007). Five of the infected neonates presented with aseptic meningitis (23.8%) underwent brain magnetic resonance imaging examination and no craniocerebral injuries were found. Subsequent follow-ups were performed in 15 of them (71.4%) and no neurological sequelae was found.Aseptic meningitis is a common type of enterovirus infection in neonates with a benign course. Nucleic acid detection of CSF has an important diagnostic value. Febrile neonates would be suggested to screen for enterovirus infection in addition to complete septic workup. An unnecessary initiation or earlier cessation of antibiotics could be considered in enterovirus infection, but that indications still need further studies to guarantee the safety.<br />Competing Interests: The authors report no conflicts of interest.<br /> (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Subjects :
- Brain diagnostic imaging
China epidemiology
Enterovirus genetics
Enterovirus Infections cerebrospinal fluid
Enterovirus Infections diagnosis
Enterovirus Infections virology
Exanthema cerebrospinal fluid
Exanthema diagnosis
Exanthema epidemiology
Exanthema virology
Female
Fever cerebrospinal fluid
Fever diagnosis
Fever virology
Humans
Incidence
Infant, Newborn
Intensive Care Units, Neonatal statistics & numerical data
Magnetic Resonance Imaging
Male
Meningitis, Aseptic cerebrospinal fluid
Meningitis, Aseptic diagnosis
Meningitis, Aseptic virology
Meningitis, Viral cerebrospinal fluid
Meningitis, Viral diagnosis
Meningitis, Viral virology
Pharynx virology
RNA, Viral cerebrospinal fluid
RNA, Viral isolation & purification
Retrospective Studies
Skin Diseases, Viral cerebrospinal fluid
Skin Diseases, Viral epidemiology
Skin Diseases, Viral virology
Enterovirus isolation & purification
Enterovirus Infections epidemiology
Fever epidemiology
Meningitis, Aseptic epidemiology
Meningitis, Viral epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 100
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33950953
- Full Text :
- https://doi.org/10.1097/MD.0000000000025706