Back to Search
Start Over
Minimum inhibitory concentration (MIC) of Ceftriaxone and Azithromycin for blood culture isolates of Salmonella enterica spp.
- Source :
-
Journal of infection in developing countries [J Infect Dev Ctries] 2021 Apr 30; Vol. 15 (4), pp. 538-543. Date of Electronic Publication: 2021 Apr 30. - Publication Year :
- 2021
-
Abstract
- Introduction: Enteric fever caused by Salmonella enterica continues to be a major public health problem worldwide. In the last decade, ceftriaxone and azithromycin have become the drugs of choice for treating enteric fever caused by Nalidixic acid resistant Salmonella (NARS) enterica. This has led to reports of drug resistance to both drugs. Since enteric fever is endemic in India, accurate drug susceptibility surveillance is crucial to ensure empiric management of enteric fever is appropriate. The aim of this study is to evaluate the minimum inhibitory concentration (MIC) of ceftriaxone and azithromycin for blood culture isolates of NARS isolated at our centre.<br />Methodology: This is a retrospective study conducted in a tertiary care center in Mumbai for blood culture isolates of NARS from 2016 to 2018. Isolates were tested for antimicrobial susceptibility testing (AST) against ceftriaxone and azithromycin using a manual broth microdilution method (BMD).<br />Results: Of 155 blood culture isolates of NARS: S. Typhi (n = 112) and S. Paratyphi A (n = 43) were included in the study. 81.9% (127 / 155) isolates were susceptible, 6.4% (10 / 155) isolates were intermediate while 11.6% (18 / 155) isolates were resistant to ceftriaxone. 100% susceptibility of NARS was observed to azithromycin.<br />Conclusions: This study documents an alarming increase in resistance to ceftriaxone among NARS in Mumbai while azithromycin continues to be susceptible in vitro. It is essential to know MICs to understand epidemiological trends and choose appropriate treatment regimens for treating enteric fever.<br />Competing Interests: No Conflict of Interest is declared<br /> (Copyright (c) 2021 Rashmi Shankar Kokare, Anurag Kumar Bari, Joanna Valanie Pereira, Kinjal Patel, Aruna Poojary.)
- Subjects :
- Azithromycin administration & dosage
Azithromycin pharmacokinetics
Ceftriaxone administration & dosage
Ceftriaxone pharmacokinetics
Humans
India
Microbial Sensitivity Tests methods
Retrospective Studies
Salmonella enterica isolation & purification
Typhoid Fever drug therapy
Azithromycin blood
Ceftriaxone blood
Drug Resistance, Bacterial drug effects
Typhoid Fever microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1972-2680
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of infection in developing countries
- Publication Type :
- Academic Journal
- Accession number :
- 33956654
- Full Text :
- https://doi.org/10.3855/jidc.13454