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Effect of intermittent and continuous caloric restriction on Sirtuin1 concentration depends on sex and body mass index.
- Source :
-
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Jun 07; Vol. 31 (6), pp. 1871-1878. Date of Electronic Publication: 2021 Mar 19. - Publication Year :
- 2021
-
Abstract
- Background & Aims: The favorable effect of caloric restriction (CR) on health span is well known and partly mediated by the sirtuin system. Sirtuin1, a regulator of energy homeostasis in response to nutrient availability, is activated by CR. We therefore investigated effects of two different CR regimens on Sirtuin1 concentrations.<br />Methods & Results: The study included 112 abdominally obese subjects, randomized to intermittent or continuous CR for 1 year. Blood samples and anthropometric measures were collected at baseline and after 12 months. Sirtuin1 concentrations were measured by ELISA. Sirtuin1 correlated significantly to BMI at baseline (r = .232, p = 0.019). Mean reduction in body-weight was 8.0 and 9.0 kg after intermittent and continuous CR, respectively. After 1 year, no significant between-group differences in Sirtuin1 levels were observed according to regimen (p = 0.98) and sex (p = 0.41). An increase in median Sirtuin1 concentrations (pg/mL) [25, 75 percentiles] from baseline was observed after intermittent CR in the total population (884 [624, 1285] vs.762 [530, 1135]; p = 0.041), most marked in men (820 [623, 1250] vs. 633 [524, 926]; p = 0.016). Improvement in BMI after 1 year correlated to Sirtuin1 changes, but varied according to sex. In women, Spearman's rho = .298, p = 0.034, with stronger correlation in the intermittent CR group (r = .424, p = 0.049). In men, there was an inverse relation to Sirtuin1 changes, only in the intermittent CR group (r = -.396, p = 0.045).<br />Conclusions: Effects on Sirtuin1 concentrations after 1 year of CR are sex and BMI-related. Intermittent CR regimen affected Sirtuin1 to a stronger extent than continuous CR, suggesting individualized dietary intervention.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Biomarkers blood
Cardiometabolic Risk Factors
Female
Humans
Male
Middle Aged
Norway
Obesity, Abdominal blood
Obesity, Abdominal diagnosis
Obesity, Abdominal enzymology
Sex Factors
Time Factors
Treatment Outcome
Young Adult
Body Mass Index
Caloric Restriction
Fasting
Obesity, Abdominal diet therapy
Sirtuin 1 blood
Weight Loss
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3729
- Volume :
- 31
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nutrition, metabolism, and cardiovascular diseases : NMCD
- Publication Type :
- Academic Journal
- Accession number :
- 33975734
- Full Text :
- https://doi.org/10.1016/j.numecd.2021.03.005