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A Global Vista of the Epigenomic State of the Mouse Submandibular Gland.

Authors :
Gluck C
Min S
Oyelakin A
Che M
Horeth E
Song EAC
Bard J
Lamb N
Sinha S
Romano RA
Source :
Journal of dental research [J Dent Res] 2021 Dec; Vol. 100 (13), pp. 1492-1500. Date of Electronic Publication: 2021 May 12.
Publication Year :
2021

Abstract

The parotid, submandibular, and sublingual glands represent a trio of oral secretory glands whose primary function is to produce saliva, facilitate digestion of food, provide protection against microbes, and maintain oral health. While recent studies have begun to shed light on the global gene expression patterns and profiles of salivary glands, particularly those of mice, relatively little is known about the location and identity of transcriptional control elements. Here we have established the epigenomic landscape of the mouse submandibular salivary gland (SMG) by performing chromatin immunoprecipitation sequencing experiments for 4 key histone marks. Our analysis of the comprehensive SMG data sets and comparisons with those from other adult organs have identified critical enhancers and super-enhancers of the mouse SMG. By further integrating these findings with complementary RNA-sequencing based gene expression data, we have unearthed a number of molecular regulators such as members of the Fox family of transcription factors that are enriched and likely to be functionally relevant for SMG biology. Overall, our studies provide a powerful atlas of cis -regulatory elements that can be leveraged for better understanding the transcriptional control mechanisms of the mouse SMG, discovery of novel genetic switches, and modulating tissue-specific gene expression in a targeted fashion.

Details

Language :
English
ISSN :
1544-0591
Volume :
100
Issue :
13
Database :
MEDLINE
Journal :
Journal of dental research
Publication Type :
Academic Journal
Accession number :
33978512
Full Text :
https://doi.org/10.1177/00220345211012000