Back to Search
Start Over
Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2021 May 17; Vol. 21 (1), pp. 446. Date of Electronic Publication: 2021 May 17. - Publication Year :
- 2021
-
Abstract
- Background: Coxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans.<br />Methods: A molecular epidemiological investigation of CVA21 was conducted among patients presenting with acute upper respiratory illnesses in the ambulatory settings between 2012 and 2014 in Kuala Lumpur, Malaysia.<br />Results: Epidemiological surveillance of acute respiratory infections (nā=ā3935) showed low-level detection of CVA21 (0.08%, 1.4 cases/year) in Kuala Lumpur, with no clear seasonal distribution. Phylogenetic analysis of the new complete genomes showed close relationship with CVA21 strains from China and the United States. Spatio-temporal mapping of the VP1 gene determined 2 major clusters circulating worldwide, with inter-country lineage migration and strain replacement occurring over time.<br />Conclusions: The study highlights the emerging role of CVA21 in causing sporadic acute respiratory outbreaks.
- Subjects :
- Adolescent
Adult
Capsid Proteins classification
Capsid Proteins genetics
Coxsackievirus Infections epidemiology
Coxsackievirus Infections virology
Disease Outbreaks
Enterovirus classification
Enterovirus isolation & purification
Female
Humans
Malaysia epidemiology
Male
Middle Aged
Phylogeny
Respiratory Tract Infections epidemiology
Respiratory Tract Infections virology
Coxsackievirus Infections diagnosis
Enterovirus genetics
Genetic Variation
Respiratory Tract Infections diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 34001016
- Full Text :
- https://doi.org/10.1186/s12879-021-06148-x