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ABO genotypes and the risk of esophageal and gastric cancers.
- Source :
-
BMC cancer [BMC Cancer] 2021 May 22; Vol. 21 (1), pp. 589. Date of Electronic Publication: 2021 May 22. - Publication Year :
- 2021
-
Abstract
- Background: Blood type has been associated with the risk of gastric cancer, but few studies have examined the association with esophageal squamous cell carcinoma (ESCC).<br />Methods: We conducted a case-control study using genotyping data of Chinese individuals, including cases of 2022 ESCC, 1189 gastric cardia adenocarcinoma, 1161 gastric noncardia adenocarcinoma, and 2696 controls. Genetic blood type was imputed using three single nucleotide polymorphisms. We used logistic regression to examine the association between blood type and the risk of each cancer.<br />Results: Compared to blood type O, the risk of ESCC was significantly elevated for blood type B and AB, with the highest risk for type AB (OR, 95%CI: 1.34, 1.07-1.67). Analysis of genotype suggested that the association of ESCC was from carrying the B allele. Similarly, blood type was significantly associated with gastric noncardia adenocarcinoma (Pā<ā0.001) with risk significantly elevated in type A (1.37, 1.14-1.65) and AB (1.44, 1.10-1.89) compared to type O. Blood type was not associated with gastric cardia adenocarcinoma (Pā=ā0.13).<br />Conclusions: This study provides novel insights into the association between blood type and the risk of ESCC and restricted previously observed association to only gastric noncardia cancer, providing important evidence to clarify the pattern of association and suggesting mechanisms of action.
- Subjects :
- Adenocarcinoma blood
Asian People genetics
Case-Control Studies
China epidemiology
Esophageal Neoplasms blood
Esophageal Squamous Cell Carcinoma blood
Female
Genotyping Techniques
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Assessment methods
Stomach Neoplasms blood
ABO Blood-Group System genetics
Adenocarcinoma epidemiology
Esophageal Neoplasms epidemiology
Esophageal Squamous Cell Carcinoma epidemiology
Stomach Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 34022824
- Full Text :
- https://doi.org/10.1186/s12885-021-08334-1