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Polymerized albumin restores impaired hemodynamics in endotoxemia and polymicrobial sepsis.
- Source :
-
Scientific reports [Sci Rep] 2021 May 25; Vol. 11 (1), pp. 10834. Date of Electronic Publication: 2021 May 25. - Publication Year :
- 2021
-
Abstract
- Fluid resuscitation following severe inflammation-induced hypoperfusion is critical for the restoration of hemodynamics and the prevention of multiorgan dysfunction syndrome during septic shock. Fluid resuscitation with commercially available crystalloid and colloid solutions only provides transient benefits, followed by fluid extravasation and tissue edema through the inflamed endothelium. The increased molecular weight (M.W.) of polymerized human serum albumin (PolyHSA) can limit fluid extravasation, leading to restoration of hemodynamics. In this prospective study, we evaluated how fluid resuscitation with PolyHSA impacts the hemodynamic and immune response in a lipopolysaccharide (LPS) induced endotoxemia mouse model. Additionally, we evaluated fluid resuscitation with PolyHSA in a model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Resuscitation with PolyHSA attenuated the immune response and improved the maintenance of systemic hemodynamics and restoration of microcirculatory hemodynamics. This decrease in inflammatory immune response and maintenance of vascular wall shear stress likely contributes to the maintenance of vascular integrity following fluid resuscitation with PolyHSA. The sustained restoration of perfusion, decrease in pro-inflammatory immune response, and improved vascular integrity that results from the high M.W. of PolyHSA indicates that a PolyHSA based solution is a potential resuscitation fluid for endotoxic and septic shock.
- Subjects :
- Animals
Cytokines metabolism
Disease Models, Animal
Endotoxemia chemically induced
Endotoxemia immunology
Gene Expression Regulation drug effects
Hemodynamics drug effects
Lipopolysaccharides adverse effects
Male
Mesocricetus
Mice
Prospective Studies
Serum Albumin, Human pharmacology
Shock, Septic etiology
Shock, Septic immunology
Endotoxemia drug therapy
Fluid Therapy methods
Microcirculation drug effects
Serum Albumin, Human administration & dosage
Shock, Septic drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34035380
- Full Text :
- https://doi.org/10.1038/s41598-021-90431-z