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Chemical Profile, Cytotoxic Activity and Oxidative Stress Reduction of Different Syringa vulgaris L. Extracts.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2021 May 22; Vol. 26 (11). Date of Electronic Publication: 2021 May 22. - Publication Year :
- 2021
-
Abstract
- Syringa vulgaris L. (common lilac) is one of the most popular ornamental species, but also a promising not comprehensively studied source of bioactive compounds with important therapeutic potential. Our study was designed to characterize the chemical composition and to assess the antioxidant and cytotoxic properties of ethanolic extracts obtained from S. vulgaris L. flowers, leaves, bark, and fruit. The chemical profile of the ethanolic extracts was investigated using chromatographic (HPLC-DAD-ESI <superscript>+</superscript> , GC-MS) and spectral (UV-Vis, FT-IR) methods, while the protective effect against free radicals was evaluated in vitro by different chemical assays (DPPH, FRAP, CUPRAC). The cytotoxic activity was tested on two tumoral cell lines, HeLa, B16F10, using the MTT assay. Significant amounts of free or glycosylated chemical components belonging to various therapeutically important structural classes, such as phenyl-propanoids (syringin, acteoside, echinacoside), flavonoids (quercetin, kaempferol derivatives) and secoiridoids (secologanoside, oleuropein, 10 -hydroxy oleuropein, demethyloleuropein, syringalactone A, nuzhenide, lingstroside) were obtained for the flowers, leaves and bark extracts, respectively. Furthermore, MTT tests pointed out a significant cytotoxic potential expressed in a non-dose-dependent manner toward the tumoral lines. The performed methods underlined that S. vulgaris extracts, in particular belonging to flowers and leaves, represent valuable sources of compounds with antioxidant and antitumoral potential.
- Subjects :
- Animals
Cell Line, Tumor
Chromatography, High Pressure Liquid
Flavonoids analysis
Gas Chromatography-Mass Spectrometry
Glucosides
Glycosides
HeLa Cells
Humans
Melanoma, Experimental
Mice
Phenols
Phenylpropionates
Plant Leaves metabolism
Quercetin analysis
Spectroscopy, Fourier Transform Infrared
Antioxidants chemistry
Flowers chemistry
Oxidative Stress
Plant Extracts chemistry
Plant Leaves chemistry
Syringa chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 26
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 34067400
- Full Text :
- https://doi.org/10.3390/molecules26113104