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Hepatitis C Virus Epitope Immunodominance and B Cell Repertoire Diversity.
- Source :
-
Viruses [Viruses] 2021 May 25; Vol. 13 (6). Date of Electronic Publication: 2021 May 25. - Publication Year :
- 2021
-
Abstract
- Despite the advent of effective, curative treatments for hepatitis C virus (HCV), a preventative vaccine remains essential for the global elimination of HCV. It is now clear that the induction of broadly neutralising antibodies (bNAbs) is essential for the rational design of such a vaccine. This review details the current understanding of epitopes on the HCV envelope, characterising the potency, breadth and immunodominance of antibodies induced against these epitopes, as well as describing the interactions between B-cell receptors and HCV infection, with a particular focus on bNAb heavy and light chain variable gene usage. Additionally, we consider the importance of a public repertoire for antibodies against HCV, compiling current knowledge and suggesting that further research in this area may be critical to the rational design of an effective HCV vaccine.
- Subjects :
- Antibodies, Monoclonal immunology
Antibodies, Neutralizing immunology
B-Lymphocytes classification
Broadly Neutralizing Antibodies immunology
Epitope Mapping
Hepacivirus genetics
Hepatitis C virology
Hepatitis C Antibodies immunology
Humans
Viral Hepatitis Vaccines immunology
B-Lymphocytes immunology
Hepacivirus immunology
Immunodominant Epitopes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 34070572
- Full Text :
- https://doi.org/10.3390/v13060983