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Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin Conditions.
- Source :
-
Stem cells and development [Stem Cells Dev] 2021 Aug 01; Vol. 30 (15), pp. 758-772. Date of Electronic Publication: 2021 Jul 05. - Publication Year :
- 2021
-
Abstract
- Cytokine storm is recognized as one of the factors contributing to organ failures and mortality in patients with COVID-19. Due to chronic inflammation, COVID-19 patients with diabetes mellitus (DM) or renal disease (RD) have more severe symptoms and higher mortality. However, the factors that contribute to severe outcomes of COVID-19 patients with DM and RD have received little attention. In an effort to investigate potential treatments for COVID-19, recent research has focused on the immunomodulation functions of mesenchymal stem cells (MSCs). In this study, the correlation between DM and RD and the severity of COVID-19 was examined by a combined approach with a meta-analysis and experimental research. The results of a systematic review and meta-analysis suggested that the odd of mortality in patients with both DM and RD was increased in comparison to those with a single comorbidity. In addition, in the experimental research, the data showed that high glucose and uremic toxins contributed to the induction of cytokine storm in human lung adenocarcinoma epithelial cells (Calu-3 cells) in response to SARS-CoV Peptide Pools. Of note, the incorporation of Wharton's jelly MSC-derived extracellular vesicles (WJ-EVs) into SARS-CoV peptide-induced Calu-3 resulted in a significant decrease in nuclear NF-κB p65 and the downregulation of the cytokine storm under high concentrations of glucose and uremic toxins. This clearly suggests the potential for WJ-EVs to reduce cytokine storm reactions in patients with both chronic inflammation diseases and viral infection.
- Subjects :
- Adult
Aged
COVID-19 blood
COVID-19 complications
COVID-19 metabolism
COVID-19 therapy
Cells, Cultured
Coculture Techniques
Cytokine Release Syndrome genetics
Cytokine Release Syndrome metabolism
Cytokine Release Syndrome virology
Cytokines genetics
Cytokines metabolism
Diabetes Complications blood
Diabetes Complications metabolism
Diabetes Complications therapy
Diabetes Complications virology
Diabetes Mellitus blood
Diabetes Mellitus metabolism
Diabetes Mellitus therapy
Diabetes Mellitus virology
Dose-Response Relationship, Drug
Female
Gene Expression Regulation drug effects
Glucose metabolism
Glucose pharmacology
Humans
Inflammation Mediators metabolism
Male
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells physiology
Pregnancy
Toxins, Biological metabolism
Toxins, Biological pharmacology
Umbilical Cord cytology
Uremia blood
Uremia complications
Uremia metabolism
Uremia therapy
Cytokine Release Syndrome prevention & control
Extracellular Vesicles physiology
Mesenchymal Stem Cells cytology
SARS-CoV-2 physiology
Wharton Jelly cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8534
- Volume :
- 30
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Stem cells and development
- Publication Type :
- Academic Journal
- Accession number :
- 34074129
- Full Text :
- https://doi.org/10.1089/scd.2021.0065