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Developing the right tools for the job: Lin28 regulation of early life T-cell development and function.
- Source :
-
The FEBS journal [FEBS J] 2022 Aug; Vol. 289 (15), pp. 4416-4429. Date of Electronic Publication: 2021 Jun 17. - Publication Year :
- 2022
-
Abstract
- T cells comprise a functionally heterogeneous cell population that has important roles in the immune system. While T cells are broadly considered to be a component of the antigen-specific adaptive immune response, certain T-cell subsets display innate-like effector characteristics whereas others perform immunosuppressive functions. These functionally diverse T-cell populations preferentially arise at different stages of ontogeny and are tailored to the immunological priorities of the organism over time. Many differences in early life versus adult T-cell phenotypes can be attributed to the cell-intrinsic properties of the distinct progenitors that seed the thymus throughout development. It is becoming clear that Lin28, an evolutionarily conserved, heterochronic RNA-binding protein that is differentially expressed among early life and adult hematopoietic progenitor cells, plays a substantial role in influencing early T-cell development and function. Here, we discuss the mechanisms by which Lin28 shapes the T-cell landscape to protect the developing fetus and newborn. Manipulation of the Lin28 gene regulatory network is being considered as one means of improving hematopoietic stem cell transplant outcomes; as such, understanding the impact of Lin28 on T-cell function is of clinical relevance.<br /> (© 2021 Federation of European Biochemical Societies.)
Details
- Language :
- English
- ISSN :
- 1742-4658
- Volume :
- 289
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- The FEBS journal
- Publication Type :
- Academic Journal
- Accession number :
- 34077615
- Full Text :
- https://doi.org/10.1111/febs.16045