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In Vivo Assessment of Mitochondrial Oxygen Consumption.

Authors :
Harms FA
Mik EG
Source :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2277, pp. 175-185.
Publication Year :
2021

Abstract

The Protoporphyrin IX-Triplet State Lifetime Technique (PpIX-TSLT) has been proposed by us as a potential clinical noninvasive tool for monitoring mitochondrial function. We have been working on the development of mitochondrial respirometry for monitoring mitochondrial oxygen tension (mitoPO <subscript>2</subscript> ) and mitochondrial oxygen consumption (mitoVO <subscript>2</subscript> ) in skin. In this work, we describe the principles of the method in small experimental animals.

Details

Language :
English
ISSN :
1940-6029
Volume :
2277
Database :
MEDLINE
Journal :
Methods in molecular biology (Clifton, N.J.)
Publication Type :
Academic Journal
Accession number :
34080152
Full Text :
https://doi.org/10.1007/978-1-0716-1270-5_12