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Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats.
- Source :
-
Andrologia [Andrologia] 2021 Sep; Vol. 53 (8), pp. e14117. Date of Electronic Publication: 2021 Jun 03. - Publication Year :
- 2021
-
Abstract
- This study aimed to investigate the protective effect of sinapic acid (SA) on biochemical and histopathological changes in an experimental testicular torsion-detorsion rat model. Twenty-four rats were randomised into four groups: sham group, ischemia/reperfusion (IR) group subjected to testicular torsion for 2 hr and then detorsion for 4 hr, and two groups treated with SA1 and SA2 (10 mg/kg and 20 mg/kg, by single intraperitoneal injection, 30 min before reperfusion). Serum testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured by an autoanalyzer, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), protein carbonyl (PC), and nitric oxide (NO) oxidative stress parameters by spectrophotometric methods, and tumour necrosis factor (TNF-α), interleukin-1 beta (IL-1β), and interleukin 6 (IL-6) parameters by the Elisa method. In addition, immunohistochemical and histopathological examinations were performed on testicular tissues. There was no significant difference between the groups in terms of serum testosterone, FSH and LH levels (p > .05). SA significantly reduced increased testicular damage, oxidative stress, inflammation, cell death and also restored decreased antioxidant enzyme activities (p < .05). Pre-treatment of rats with SA reduced testicular dysfunction and morphological changes IRI. SA's antioxidant, anti-inflammatory, and antiapoptotic properties were found to be protective against testicular IR.<br /> (© 2021 Wiley-VCH GmbH.)
- Subjects :
- Animals
Coumaric Acids pharmacology
Coumaric Acids therapeutic use
Humans
Male
Malondialdehyde metabolism
Oxidative Stress
Rats
Rats, Wistar
Testis metabolism
Reperfusion Injury drug therapy
Reperfusion Injury metabolism
Reperfusion Injury prevention & control
Spermatic Cord Torsion complications
Spermatic Cord Torsion drug therapy
Spermatic Cord Torsion metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0272
- Volume :
- 53
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Andrologia
- Publication Type :
- Academic Journal
- Accession number :
- 34081348
- Full Text :
- https://doi.org/10.1111/and.14117