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No association between frailty index and epigenetic clocks in Italian semi-supercentenarians.
- Source :
-
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Jul; Vol. 197, pp. 111514. Date of Electronic Publication: 2021 Jun 04. - Publication Year :
- 2021
-
Abstract
- Centenarians experience successful ageing, although they still present high heterogeneity in their health status. The frailty index is a biomarker of biological age, able to capture such heterogeneity, even at extreme old age. At the same time, other biomarkers (e.g., epigenetic clocks) may be informative the biological age of the individual and potentially describe the ageing status in centenarians. In this article, we explore the relationship between epigenetic clocks and frailty index in a cohort of Italian centenarians. No association was reported, suggesting that these two approaches may describe different aspects of the same ageing process.<br /> (Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-6216
- Volume :
- 197
- Database :
- MEDLINE
- Journal :
- Mechanisms of ageing and development
- Publication Type :
- Academic Journal
- Accession number :
- 34098514
- Full Text :
- https://doi.org/10.1016/j.mad.2021.111514