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COVID-19 in CKD Patients: Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease.

Authors :
Román JL
García-Carro C
Agraz I
Toapanta N
Vergara A
Gabaldón A
Torres I
Bury R
Baldallo C
Serón D
Soler MJ
Source :
Kidney & blood pressure research [Kidney Blood Press Res] 2021; Vol. 46 (4), pp. 452-459. Date of Electronic Publication: 2021 Jun 07.
Publication Year :
2021

Abstract

Introduction: Chronic kidney disease (CKD) patients infected with COVID-19 are at risk of serious complications such as hospitalization and death. The prognosis and lethality of COVID-19 infection in patients with established kidney disease has not been widely studied.<br />Methods: Data included patients who underwent kidney biopsy at the Vall d'Hebron Hospital between January 2013 and February 2020 with COVID-19 diagnosis during the period from March 1 to May 15, 2020.<br />Results: Thirty-nine (7%) patients were diagnosed with COVID-19 infection. Mean age was 63 ± 15 years and 48.7% were male. Hypertension was present in 79.5%, CKD without renal replacement therapy in 76.9%, and cardiovascular disease in 64.1%. Nasopharyngeal swab was performed in 26 patients; older (p = 0.01), hypertensive (p = 0.005), and immunosuppressed (p = 0.01) patients, those using RAS-blocking drugs (p = 0.04), and those with gastrointestinal symptoms (p = 0.02) were more likely to be tested for CO-VID-19. Twenty-two patients required hospitalization and 15.4% died. In bivariate analysis, mortality was associated with older age (p = 0.03), cardiovascular disease (p = 0.05), chronic obstructive pulmonary disease (p = 0.05), and low hemoglobin levels (p = 0.006). Adjusted Cox regression showed that low hemoglobin levels at admission had 1.81 greater risk of mortality.<br />Conclusions: Patients with CO-VID-19 infection and kidney disease confirmed by kidney biopsy presented a mortality of 15.4%. Swab test for COVID-19 was more likely to be performed in older, hypertensive, and immunosuppressed patients, those using RAS-blocking drugs, and those with gastrointestinal symptoms. Low hemoglobin is a risk factor for mortality.<br /> (© 2021 The Author(s) Published by S. Karger AG, Basel.)

Details

Language :
English
ISSN :
1423-0143
Volume :
46
Issue :
4
Database :
MEDLINE
Journal :
Kidney & blood pressure research
Publication Type :
Academic Journal
Accession number :
34098555
Full Text :
https://doi.org/10.1159/000515714