A ratiometric electrochemical sensor for selectively monitoring monoamine oxidase A in the live brain.

Authors :: Zhang C
Tang C
Mei Y
Zhang L
Zhu A
Tian Y
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Jul 07; Vol. 57 (53), pp. 6487-6490. Date of Electronic Publication: 2021 Jun 08.
Publication Year :: 2021
Abstract: Herein, an electrochemical method for selectively sensing and accurately quantifying monoamine oxidase A (MAO-A) in the cortex and thalamus of a live mouse brain was reported. Using this tool, it was found that MAO-A increased Ca <superscript>2+</superscript> entry into neurons via the TPRM2 channel in the live mouse brain of an AD model.

Subjects :: Animals
Cerebral Cortex enzymology
Mice
Thalamus enzymology
Brain enzymology
Electrochemistry instrumentation
Monoamine Oxidase metabolism

Full Text Access

Tools